Publications

For examples of work carried out by AIC faculty, staff and collaborators, please refer to the following publications:

2022

Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain. Lam F, Chu J, Choi JS, Cao C, Hitchens TK, Silverman SK, Liang ZP, Dilger RN, Robinson GE, Li KC. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2119891119. PMID: 35235458

Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia. Zhou C, Sun P, Xu Y, Chen Y, Huang Y, Hamblin MH, Foley L, Hitchens TK, Li S, Yin KJ. Adv Sci (Weinh). 2022 Apr 11:e2104986. PMID: 35403823

Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using 19F MRI. Modo M, Ghuman H, Azar R, Krafty R, Badylak SF, Hitchens TK. Biomaterials. 2022 Mar;282:121386. PMID: 35093825

A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo. Murdock MH, Hussey GS, Chang JT, Hill RC, Nascari DG, Rao AV, Hansen KC, Foley LM, Hitchens TK, Amankulor NM, Badylak SF. Oncotarget. 2022 Feb 21;13:426-438 PMID: 35198102

2021

Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury. Pu H, Ma C, Zhao Y, Wang Y, Zhang W, Miao W, Yu F, Hu X, Shi Y, Leak RK, Hitchens TK, Dixon CE, Bennett MV, Chen J. J Cereb Blood Flow Metab. 2021 Jul 14:271678X211028680. PMID: 34259069

Novel theranostic agent for PET imaging and targeted radiopharmaceutical therapy of tumour-infiltrating immune cells in glioma. Foster A, Nigam S, Tatum DS, Raphael I, Xu J, Kumar R, Plakseychuk E, Latoche JD, Vincze S, Li B, Giri R, McCarl LH, Edinger R, Ak M, Peddagangireddy V, Foley LM, Hitchens TK, Colen RR, Pollack IF, Panigrahy A, Magda D, Anderson CJ, Edwards WB, Kohanbash G. EBioMedicine. 2021 Sep;71:103571.. PMID: 34530385

Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate. Saito T, Hitchens TK, Foley LM, Singh N, Mizoguchi S, Kurobe M, Gotoh D, Ogawa T, Minagawa T, Ishizuka O, Chermansky C, Kaufman J, Yoshimura N, Tyagi P. Sci Rep. 2021 Sep 30;11(1):19440. PMID: 34593876

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Shi L, Sun Z, Su W, Xu F, Xie D, Zhang Q, Dai X, Iyer K, Hitchens TK, Foley LM, Li S, Stolz DB, Chen K, Ding Y, Thomson AW, Leak RK, Chen J, Hu X. Immunity. 2021 Jul 13;54(7):1527-1542.e8. PMID: 34015256

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. Liu Q, Bhuiyan MIH, Liu R, Song S, Begum G, Young CB, Foley LM, Chen F, Hitchens TK, Cao G, Chattopadhyay A, He L, Sun D. J Neuroinflammation. 2021 Aug 28;18(1):187. PMID: 34454529

Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ. Pu H, Zheng X, Jiang X, Mu H, Xu F, Zhu W, Ye Q, Jizhang Y, Hitchens TK, Shi Y, Hu X, Leak RK, Dixon CE, Bennett MV, Chen J. J Cereb Blood Flow Metab. 2021 Mar;41(3):511-529PMID: 32757740

Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells. Hasan MN, Luo L, Ding D, Song S, Bhuiyan MIH, Liu R, Foley LM, Guan X, Kohanbash G, Hitchens TK, Castro MG, Zhang Z, Sun D. Theranostics. 2021 Jan 1;11(3):1295-1309. PMID: 33391535

Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer. Dilly AK, Honick BD, Frederick R, Elapavaluru A, Velankar S, Makala H, Hitchens TK, Foley LM, Guo J, Beumer JH, Rigatti LH, Lee YJ, Bartlett DL, Choudry HA. Transl Res. 2021 Mar;229:100-114. Epub 2020 Oct 22. PMID: 33164812

Low duty cycle pulse trains for exchange rate insensitive chemical exchange saturation transfer MRI. Chung JJ, Jin T. Magn Reson Med. 2021 Jul 1 PMID: 34196028

Chemical exchange sensitive MRI of glucose uptake using xylose as a contrast agent. Wang J, Fukuda M, Chung JJ, Wang P, Jin T. Magn Reson Med. 2021 Apr;85(4):1953-1961. doi: 10.1002/mrm.28557. PMID: 33107108

Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses. Poplawsky AJ, Iordanova B, Vazquez AL, Kim SG, Fukuda M. Neuroimage. 2021 Jan 15;225:117457 PMID: 33069862

Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling. Fukuda M, Poplawsky AJ, Kim SG. Philos Trans R Soc Lond B Biol Sci. 2021 Jan 4;376(1815):20190623. PMID: 33190606

2020

Design of Thermoresponsive Polyamine Cross-Linked Perfluoropolyether Hydrogels for Imaging and Delivery Applications. Herneisey, M.; Salcedo, P. F.; Domenech, T.; Bagia, C.; George, S. S.; Tunney, R.; Velankar, S.; Hitchens, T. K.; Janjic, J. M. ACS Med. Chem. Lett. 11,2032-2040, 2020. ACS journals

Ex vivo mesoscopic diffusion MRI correlates with seizure frequency in patients with uncontrolled mesial temporal lobe epilepsy. Ke J, Foley LM, Hitchens TK, Richardson RM, Modo M. Hum Brain Mapp. 2020 Jul 21. Online ahead of print. PMID: 32691978

Virtual Measurements of Paracellular Permeability and Chronic Inflammation Via Color Coded Pixel-wise T1 Mapping. Singh N, Zabbarova I, Ikeda Y, Maranchie J, Chermansky C, Foley LM, Hitchens TK, Yoshimura N, Kanai AJ, Kaufman J, Tyagi P. Am J Physiol Renal Physiol. 2020 Jul 27. Online ahead of print. PMID: 32715761

Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus. Ly M, Foley L, Manivannan A, Hitchens TK, Richardson RM, Modo M. Hum Brain Mapp. 2020. Online ahead of print. PMID: 32621364

Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh MB, Poloyac SM, Alper SL, Molyneaux BJ, Trevelyan AJ, Kahle KT, Sun D, Deng X. Nat Commun. 2020 11(1):78. PMID: 31911626

Aberrant ER Stress Induced Neuronal-IFNβ Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI. Sen T, Saha P, Gupta R, Foley LM, Jiang T, Abakumova OS, Hitchens TK, Sen N. J Neurosci. 2020 40(2):424-446. PMID: 31694961

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia. Dai X, Chen J, Xu F, Zhao J, Cai W, Sun Z, Hitchens TK, Foley LM, Leak RK, Chen J, Hu X. J Cereb Blood Flow Metab. 2020 40(3):639-655. PMID:30834805

2019

Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane. Singh KB, Hahm ER, Alumkal JJ, Foley LM, Hitchens TK, Shiva SS, Parikh RA, Jacobs BL, Singh SV. Carcinogenesis. 2019 [Epub ahead of print] PMID: 31555797

A systematic optimization of ¹⁹F MR image acquisition to detect macrophage invasion into an ECM hydrogel implanted in the stroke-damage brain. Ghuman H, Hitchens TK, Modo M. Neuroimage. 2019 [Epub ahead of print] PMID: 31408717

Approximated analytical characterization of the steady-state chemical exchange saturation transfer (CEST) signals. Jin T, Kim SG. Magn Reson Med. 2019 82(5):1876-1889. PMID: 31237027

Dominance of layer-specific microvessel dilation in contrast-enhanced high-resolution fMRI: Comparison between hemodynamic spread and vascular architecture with CLARITY. Poplawsky AJ, Fukuda M, Kang BM, Kim JH, Suh M, Kim SG. Neuroimage. 197:657-667 PMID: 28822749

A roadmap for promoting endogenous in situ tissue restoration using inductive bioscaffolds after acute brain injury. Modo M, Badylak SF Brain Res Bull. 2019 150:136-149. PMID: 31128250

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury. Zhang Q, Zhu W, Xu F, Dai X, Shi L, Cai W, Mu H, Hitchens TK, Foley LM, Liu X, Yu F, Chen J, Shi Y, Leak RK, Gao Y, Chen J, Hu X. PLoS Biol. 2019 Jun 21;17(6):e3000330. PMID: 31226122

Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma. Chan KC, Yu Y, Ng SH, Mak HK, Yip YWY, van der Merwe Y, Ren T, Yung JSY, Biswas S, Cao X, Chau Y, Leung CKS. Acta Biomater. 2019 94:219-231. PMID: 31176841

Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function. van der Merwe Y, Faust AE, Sakalli ET, Westrick CC, Hussey G, Conner IP, Fu VLN, Badylak SF, Steketee MB. Sci Rep. 2019 9(1):3482. PMID: 30837658

Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models. Poplawsky AJ, Fukuda M, Kim SG. Neuroimage. 2019 199:718-729. PMID: 28502845

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Pu H, Shi Y, Zhang L, Lu Z, Ye Q, Leak RK, Xu F, Ma S, Mu H, Wei Z, Xu N, Xia Y, Hu X, Hitchens TK, Bennett MVL, Chen J. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9115-9124. PMID: 30996120

2018

Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke. Ghuman H, Mauney C, Donnelly J, Massensini AR, Badylak SF, Modo M. Acta Biomater. 2018 Oct 15;80:66-84. PMID: 30232030

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury. Xia Y, Pu H, Leak RK, Shi Y, Mu H, Hu X, Lu Z, Foley LM, Hitchens TK, Dixon CE, Bennett MVL, Chen J. Proc Natl Acad Sci U S A. 2018 Sep 10. pii: 201810693. doi: 10.1073/pnas.1810693115. [Epub ahead of print] PMID: 30201709

Selective role of Na+ /H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post-stroke function recovery. Song S, Wang S, Pigott VM, Jiang T, Foley LM, Mishra A, Nayak R, Zhu W, Begum G, Shi Y, Carney KE, Hitchens TK, Shull GE, Sun D. Glia. 2018 Jul 25. doi: 10.1002/glia.23456. [Epub ahead of print] PMID: 30043461

Iron Oxide Nanoparticles with Grafted Polymeric Analogue of Dimethyl Sulfoxide as Potential Magnetic Resonance Imaging Contrast Agents. Yan J, Li S, Cartieri F, Wang Z, Hitchens TK, Leonardo J, Averick SE, Matyjaszewski K. ACS Appl Mater Interfaces. 2018 Jul 5;10(26):21901-21908. doi: 10.1021/acsami.8b06416. Epub 2018 Jun 21. PMID: 29889490

Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection. Zhu Y, Matsumura Y, Velayutham M, Foley LM, Hitchens TK, Wagner WR. Biomaterials. 2018 Sep;177:98-112. doi: 10.1016/j.biomaterials.2018.05.044. Epub 2018 May 31. PMID: 29886387

The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis. Grandhi R, Peitz GW, Foley LM, Bonfield CM, Fellows-Mayle W, Hitchens TK, Mooney MP. PLoS One. 2018 Jun 1;13(6):e0197296. doi: 10.1371/journal.pone.0197296. eCollection 2018. PMID: 29856748

Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats. Fidan E, Foley LM, New LA, Alexander H, Kochanek PM, Hitchens TK, Bayır H. ASN Neuro. 2018 Jan-Dec;10:1759091418770543. doi: 10.1177/1759091418770543. PMID: 29741097

Chemical exchange-sensitive spin-lock (CESL) MRI of glucose and analogs in brain tumors. Jin T, Iordanova B, Hitchens TK, Modo M, Wang P, Mehrens H, Kim SG. Magn Reson Med. 2018 Aug;80(2):488-495. doi: 10.1002/mrm.27183. Epub 2018 Mar 23. PMID: 29569739

Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma. Yang XL, van der Merwe Y, Sims J, Parra C, Ho LC, Schuman JS, Wollstein G, Lathrop KL, Chan KC. Sci Rep. 2018 Mar 15;8(1):4643. doi: 10.1038/s41598-018-22850-4. PMID: 29545576

Enhancing sensitivity of pH-weighted MRI with combination of amide and guanidyl CEST. Jin T, Wang P, Hitchens TK, Kim SG. Neuroimage. 2017 Aug 15;157:341-350. doi: 10.1016/j.neuroimage.2017.06.007. Epub 2017 Jun 7. PMID: 28602944

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury. Yin Y, Li E, Sun G, Yan HQ, Foley LM, Andrzejczuk LA, Attarwala IY, Hitchens TK, Kiselyov K, Dixon CE, Sun D. Mol Neurobiol. 2018 Mar;55(3):2454-2470. doi: 10.1007/s12035-017-0504-8. Epub 2017 Apr 1. PMID: 28365875

Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-d-glucose in normal and ischemic brain. Jin T, Mehrens H, Wang P, Kim SG. J Cereb Blood Flow Metab. 2018 May;38(5):869-880. doi: 10.1177/0271678X17707419. Epub 2017 May 9. PMID: 28485194

2017

Novel contrast mixture improves bladder wall contrast for visualizing bladder injury. Tyagi P, Janicki JJ, Hitchens TK, Foley LM, Kashyap M, Yoshimura N, Kaufman J. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F155-F162. doi: 10.1152/ajprenal.00609.2016. Epub 2017 Mar 29. PMID: 28356290

Enduring disturbances in regional cerebral blood flow and brain oxygenation at 24 h after asphyxial cardiac arrest in developing rats. Foley LM, Clark RS, Vazquez AL, Hitchens TK, Alexander H, Ho C, Kochanek PM, Manole MD. Pediatr Res. 2017 Jan;81(1-1):94-98. doi: 10.1038/pr.2016.175. Epub 2016 Sep 16. PMID: 27636898

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Hitchens TK, Hu S, Zhang Z, Sun D. J Cereb Blood Flow Metab. 2017 Feb;37(2):550-563. doi: 10.1177/0271678X16631561. Epub 2016 Jul 20. PMID: 26861815

Mapping immune cell infiltration using restricted diffusion MRI. Yeh FC, Liu L, Hitchens TK, Wu YL. Magn Reson Med. 2017 Feb;77(2):603-612. doi: 10.1002/mrm.26143. Epub 2016 Feb 4. PMID: 26843524

Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI. Lohani S, Poplawsky AJ, Kim SG, Moghaddam B. Mol Psychiatry. 2017 Apr;22(4):585-594. doi: 10.1038/mp.2016.102. Epub 2016 Jul 26. PMID: 27457809

Chemical-exchange-sensitive MRI of amide, amine and NOE at 9.4 T versus 15.2 T. Chung JJ, Choi W, Jin T, Lee JH, Kim SG. NMR Biomed. 2017 Sep;30(9). doi: 10.1002/nbm.3740. Epub 2017 May 22. PMID: 28544035

Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke. Jin T, Nicholls FJ, Crum WR, Ghuman H, Badylak SF, Modo M. Biomaterials. 2017 Jan;113:176-190. doi: 10.1016/j.biomaterials.2016.10.043. Epub 2016 Oct 29. PMID: 27816001

Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI. Chan KC, Zhou IY, Liu SS, van der Merwe Y, Fan SJ, Hung VK, Chung SK, Wu WT, So KF, Wu EX. Sci Rep. 2017 Feb 23;7:43124. doi: 10.1038/srep43124. PMID: 28230106

MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T. Zhang XY, Wang F, Jin T, Xu J, Xie J, Gochberg DF, Gore JC, Zu Z. Magn Reson Med. 2017 Aug;78(2):588-597. doi: 10.1002/mrm.26396. Epub 2016 Sep 8. PMID: 27604612

2016

Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy. Modo M, Hitchens TK, Liu JR, Richardson RM. Hum Brain Mapp. 2016 Feb;37(2):780-95. doi: 10.1002/hbm.23066. Epub 2015 Nov 27. PMID: 26611565

Improved spatial accuracy of functional maps in the rat olfactory bulb using supervised machine learning approach. Murphy MC, Poplawsky AJ, Vazquez AL, Chan KC, Kim SG, Fukuda M. Neuroimage. 2016 Aug 15;137:1-8. doi: 10.1016/j.neuroimage.2016.05.055. Epub 2016 May 25. PMID: 27236085

Advanced Imaging Center