Publications

For examples of work carried out by AIC faculty, staff and collaborators, please refer to the following publications:

2019

A systematic optimization of 19F MR image acquisition to detect macrophage invasion into an ECM hydrogel implanted in the stroke-damage brain. Ghuman H, Hitchens TK, Modo M. Neuroimage. 2019 [Epub ahead of print] PMID: 31408717

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury.  Zhang Q, Zhu W, Xu F, Dai X, Shi L, Cai W, Mu H, Hitchens TK, Foley LM, Liu X, Yu F, Chen J, Shi Y, Leak RK, Gao Y, Chen J, Hu X. PLoS Biol. 2019 Jun 21;17(6):e3000330. PMID: 31226122

Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function.  van der Merwe, Faust AE, Sakalli ET, Westrick CC, Hussey G, Conner IP, Fu VLN, Badylak SF, Steketee MB. Sci Rep. 2019 9(1):3482. PMID: 30837658

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Pu H, Shi Y, Zhang L, Lu Z, Ye Q, Leak RK, Xu F, Ma S, Mu H, Wei Z, Xu N, Xia Y, Hu X, Hitchens TK, Bennett MVL, Chen J. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9115-9124. PMID: 30996120

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia. Dai X, Chen J, Xu F, Zhao J, Cai W, Sun Z, Hitchens TK, Foley LM, Leak RK, Chen J, Hu X. J Cereb Blood Flow Metab. 2019. [Epub ahead of print]  PMID:30834805

2018

Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke. Ghuman H, Mauney C, Donnelly J, Massensini AR, Badylak SF, Modo M. Acta Biomater. 2018 Oct 15;80:66-84. PMID: 30232030

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury. Xia Y, Pu H, Leak RK, Shi Y, Mu H, Hu X, Lu Z, Foley LM, Hitchens TK, Dixon CE, Bennett MVL, Chen J. Proc Natl Acad Sci U S A. 2018 Sep 10. pii: 201810693. doi: 10.1073/pnas.1810693115. [Epub ahead of print] PMID: 30201709

Selective role of Na+ /H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post-stroke function recovery. Song S, Wang S, Pigott VM, Jiang T, Foley LM, Mishra A, Nayak R, Zhu W, Begum G, Shi Y, Carney KE, Hitchens TK, Shull GE, Sun D. Glia. 2018 Jul 25. doi: 10.1002/glia.23456. [Epub ahead of print] PMID: 30043461

Iron Oxide Nanoparticles with Grafted Polymeric Analogue of Dimethyl Sulfoxide as Potential Magnetic Resonance Imaging Contrast Agents. Yan J, Li S, Cartieri F, Wang Z, Hitchens TK, Leonardo J, Averick SE, Matyjaszewski K. ACS Appl Mater Interfaces. 2018 Jul 5;10(26):21901-21908. doi: 10.1021/acsami.8b06416. Epub 2018 Jun 21. PMID: 29889490

Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection. Zhu Y, Matsumura Y, Velayutham M, Foley LM, Hitchens TK, Wagner WR. Biomaterials. 2018 Sep;177:98-112. doi: 10.1016/j.biomaterials.2018.05.044. Epub 2018 May 31. PMID: 29886387

The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis. Grandhi R, Peitz GW, Foley LM, Bonfield CM, Fellows-Mayle W, Hitchens TK, Mooney MP. PLoS One. 2018 Jun 1;13(6):e0197296. doi: 10.1371/journal.pone.0197296. eCollection 2018. PMID: 29856748

Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats. Fidan E, Foley LM, New LA, Alexander H, Kochanek PM, Hitchens TK, Bayır H. ASN Neuro. 2018 Jan-Dec;10:1759091418770543. doi: 10.1177/1759091418770543. PMID: 29741097

Chemical exchange-sensitive spin-lock (CESL) MRI of glucose and analogs in brain tumors. Jin T, Iordanova B, Hitchens TK, Modo M, Wang P, Mehrens H, Kim SG. Magn Reson Med. 2018 Aug;80(2):488-495. doi: 10.1002/mrm.27183. Epub 2018 Mar 23. PMID: 29569739

Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma. Yang XL, van der Merwe Y, Sims J, Parra C, Ho LC, Schuman JS, Wollstein G, Lathrop KL, Chan KC. Sci Rep. 2018 Mar 15;8(1):4643. doi: 10.1038/s41598-018-22850-4. PMID: 29545576

Enhancing sensitivity of pH-weighted MRI with combination of amide and guanidyl CEST. Jin T, Wang P, Hitchens TK, Kim SG. Neuroimage. 2017 Aug 15;157:341-350. doi: 10.1016/j.neuroimage.2017.06.007. Epub 2017 Jun 7. PMID: 28602944

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury. Yin Y, Li E, Sun G, Yan HQ, Foley LM, Andrzejczuk LA, Attarwala IY, Hitchens TK, Kiselyov K, Dixon CE, Sun D. Mol Neurobiol. 2018 Mar;55(3):2454-2470. doi: 10.1007/s12035-017-0504-8. Epub 2017 Apr 1. PMID: 28365875

Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-d-glucose in normal and ischemic brain. Jin T, Mehrens H, Wang P, Kim SG. J Cereb Blood Flow Metab. 2018 May;38(5):869-880. doi: 10.1177/0271678X17707419. Epub 2017 May 9. PMID: 28485194

2017

Novel contrast mixture improves bladder wall contrast for visualizing bladder injury. Tyagi P, Janicki JJ, Hitchens TK, Foley LM, Kashyap M, Yoshimura N, Kaufman J. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F155-F162. doi: 10.1152/ajprenal.00609.2016. Epub 2017 Mar 29. PMID: 28356290

Enduring disturbances in regional cerebral blood flow and brain oxygenation at 24 h after asphyxial cardiac arrest in developing rats. Foley LM, Clark RS, Vazquez AL, Hitchens TK, Alexander H, Ho C, Kochanek PM, Manole MD. Pediatr Res. 2017 Jan;81(1-1):94-98. doi: 10.1038/pr.2016.175. Epub 2016 Sep 16. PMID: 27636898

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Hitchens TK, Hu S, Zhang Z, Sun D. J Cereb Blood Flow Metab. 2017 Feb;37(2):550-563. doi: 10.1177/0271678X16631561. Epub 2016 Jul 20. PMID: 26861815

Mapping immune cell infiltration using restricted diffusion MRI. Yeh FC, Liu L, Hitchens TK, Wu YL. Magn Reson Med. 2017 Feb;77(2):603-612. doi: 10.1002/mrm.26143. Epub 2016 Feb 4. PMID: 26843524

Dominance of layer-specific microvessel dilation in contrast-enhanced high-resolution fMRI: Comparison between hemodynamic spread and vascular architecture with CLARITY. Poplawsky AJ, Fukuda M, Kang BM, Kim JH, Suh M, Kim SG. Neuroimage. 2017 Aug 16. pii: S1053-8119(17)30693-6. doi: 10.1016/j.neuroimage.2017.08.046. [Epub ahead of print] Review. PMID: 28822749

Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI. Lohani S, Poplawsky AJ, Kim SG, Moghaddam B. Mol Psychiatry. 2017 Apr;22(4):585-594. doi: 10.1038/mp.2016.102. Epub 2016 Jul 26. PMID: 27457809

Chemical-exchange-sensitive MRI of amide, amine and NOE at 9.4 T versus 15.2 T. Chung JJ, Choi W, Jin T, Lee JH, Kim SG. NMR Biomed. 2017 Sep;30(9). doi: 10.1002/nbm.3740. Epub 2017 May 22. PMID: 28544035

Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke. Jin T, Nicholls FJ, Crum WR, Ghuman H, Badylak SF, Modo M. Biomaterials. 2017 Jan;113:176-190. doi: 10.1016/j.biomaterials.2016.10.043. Epub 2016 Oct 29. PMID: 27816001

Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI. Chan KC, Zhou IY, Liu SS, van der Merwe Y, Fan SJ, Hung VK, Chung SK, Wu WT, So KF, Wu EX. Sci Rep. 2017 Feb 23;7:43124. doi: 10.1038/srep43124.  PMID: 28230106 

MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T. Zhang XY, Wang F, Jin T, Xu J, Xie J, Gochberg DF, Gore JC, Zu Z. Magn Reson Med. 2017 Aug;78(2):588-597. doi: 10.1002/mrm.26396. Epub 2016 Sep 8. PMID: 27604612

2016

Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy. Modo M, Hitchens TK, Liu JR, Richardson RM. Hum Brain Mapp. 2016 Feb;37(2):780-95. doi: 10.1002/hbm.23066. Epub 2015 Nov 27. PMID: 26611565

Improved spatial accuracy of functional maps in the rat olfactory bulb using supervised machine learning approach. Murphy MC, Poplawsky AJ, Vazquez AL, Chan KC, Kim SG, Fukuda M. Neuroimage. 2016 Aug 15;137:1-8. doi: 10.1016/j.neuroimage.2016.05.055. Epub 2016 May 25. PMID: 27236085